1,2-Dichlorobenzene → HCID 19736319, 화합물

HRID 326205

반응식

HRID 326205 반응식
C(O[C:12]1[CH:13]=[C:14]2[C:19](=[CH:20][CH:21]=1)[CH:18]=[C:17]([C:22]([NH:24][C:25]1[CH:30]=[C:29]([CH2:31][CH2:32][CH2:33][CH3:34])[CH:28]=[CH:27][C:26]=1[OH:35])=O)[CH:16]=[CH:15]2)CCCCCCCCC.[OH2:36].[C:37]1([CH3:47])[CH:42]=[CH:41][C:40](S(O)(=O)=O)=[CH:39][CH:38]=1.Cl[C:49]1[CH:54]=CC=C[C:50]=1Cl>>[CH2:50]([O:36][C:12]1[CH:13]=[C:14]2[C:19](=[CH:20][CH:21]=1)[CH:18]=[C:17]([C:22]1[O:35][C:26]3[CH:27]=[CH:28][C:29]([CH2:31][CH2:32][CH2:33][CH3:34])=[CH:30][C:25]=3[N:24]=1)[CH:16]=[CH:15]2)[CH2:49][CH2:54][CH2:38][CH2:39][CH2:40][CH2:41][CH2:42][CH2:37][CH3:47]

참가 물질

4

반응물 3

HCID 72391,2-Dichlorobenzene2회HCID 521998p-Toluenesulfonic acid monohydrateHCID 197363202-(6-Decyloxy-2-naphthoylamino)-4-butylphenol

생성물 1

HCID 19736319HCID 19736319, 화합물수율 48.4%

실험 절차

In a 20 ml-round-bottomed flask, 0.95 g (2.00 mM) of 2-(6-decyloxy-2-naphthoylamino)-4-butylphenol, 0.07 g of p-toluenesulfonic acid monohydrate and 8 ml of o-dichlorobenzene were placed, followed by stirring for 30 min. at 200°-203° C. After the reaction, o-dichlorbenzene dichlorobenzene was distilled-off under reduced pressure. The residue was purified by silica gel column chromatography (eluent: toluene/hexane=1/1) and recrystallized from acetone) to obtain 0.56 g of 2-(6-decyloxy-2-naphthyl)-5-butyl-benzoxazole (yield: 48.4 %). ##STR34##

후처리

  1. customThe residue was purified by silica gel column chromatography (eluent: toluene/hexane=1/1)
  2. customrecrystallized from acetone)

출처 및 근거

ORD 기록
ord-4b8c3e9cf402437bbeee77dc96fa3fa0
출처 데이터셋
uspto-grants-1993_12
특허 번호
US05268123

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