Tetrachlorophthalic anhydride → 2,3,4,5-Tetrachloro-6-[(4-chloro-3-isopropoxycarbonyl-phenyl)carbamoyl]benzoic acid

HRID 326343

반응식

HRID 326343 반응식
[Cl:1][C:2]1[C:3]([Cl:15])=[C:4]([Cl:14])[C:5]([Cl:13])=[C:6]2[C:11](=[O:12])[O:10][C:8](=[O:9])[C:7]=12.[NH2:16][C:17]1[CH:18]=[CH:19][C:20]([Cl:29])=[C:21]([CH:28]=1)[C:22]([O:24][CH:25]([CH3:27])[CH3:26])=[O:23]>C1(C)C=CC=CC=1>[Cl:13][C:5]1[C:4]([Cl:14])=[C:3]([Cl:15])[C:2]([Cl:1])=[C:7]([C:8]([NH:16][C:17]2[CH:18]=[CH:19][C:20]([Cl:29])=[C:21]([C:22]([O:24][CH:25]([CH3:27])[CH3:26])=[O:23])[CH:28]=2)=[O:9])[C:6]=1[C:11]([OH:10])=[O:12]

참가 물질

4

반응물 2

HCID 8326Tetrachlorophthalic anhydrideHCID 369590Isopropyl 5-amino-2-chlorobenzoate

생성물 1

HCID 5032772,3,4,5-Tetrachloro-6-[(4-chloro-3-isopropoxycarbonyl-phenyl)carbamoyl]benzoic acid수율 70%

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

A mixture of tetrachlorophthalic anhydride (2.97 g, 0.010 mole), 1-methylethyl 5-amino-2-chlorobenzoate (2.22 g, 0.010 mole) and toluene (100 ml) was heated slowly to reflux with stirring, then left overnight at room temperature. Filtration of the reaction mixture gave the title compound, m.p. 178°-179° C. (3.45 g, 70% yield).

후처리

  1. temperaturewas heated slowly
  2. temperatureto reflux
  3. filtrationFiltration of the reaction mixture

출처 및 근거

ORD 기록
ord-04dd752ccf414eb685ac6e3834415e2e
출처 데이터셋
uspto-grants-1993_12
특허 번호
US05268389

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