6-[4-(4-Iodophenyl)-1-methyl-1H-imidazol-5-yl]thieno[2,3-d]pyrimidin-4-amine → 6-(4-{4-[(Diphenylmethylene)amino]phenyl}-1-methyl-1H-imidazol-5-yl)thieno[2,3-d]pyrimidin-4-amine
반응식
[C:1]1([C:7](=[N:14][C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=2N2C=C(C3(N)NC=NC4SC=CC3=4)N(C)C2)[C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.IC1C=CC([C:44]2[N:45]=[CH:46][N:47]([CH3:59])[C:48]=2[C:49]2[S:58][C:52]3[N:53]=[CH:54][N:55]=[C:56]([NH2:57])[C:51]=3[CH:50]=2)=CC=1>>[C:1]1([C:7](=[N:14][C:15]2[CH:20]=[CH:19][C:18]([C:44]3[N:45]=[CH:46][N:47]([CH3:59])[C:48]=3[C:49]3[S:58][C:52]4[N:53]=[CH:54][N:55]=[C:56]([NH2:57])[C:51]=4[CH:50]=3)=[CH:17][CH:16]=2)[C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1참가 물질
3
실험 절차
The title compound was prepared by a similar process to that described for Intermediate 109 but using 6-[4-(4-iodophenyl)-1-methyl-1H-imidazol-5-yl]thieno[2,3-d]pyrimidin-4-amine (Intermediate 64) in place of 6-[4-(3-iodophenyl)-1-methyl-1H-imidazol-5-yl]thieno[2,3-d]pyrimidin-4-amine (Example 49). Colourless solid (31 mg, 64%);
출처 및 근거
- ORD 기록
- ord-019392462a1e488aa9affa3e4ae96b6f