Formaldehyde → Ethyl 7-chloro-2-oxoheptanoate

반응식

C=[O:2].S(=O)(=O)(O)O.O.[Cl:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][C:15](=NO)[C:16]([O:18][CH2:19][CH3:20])=[O:17]>>[Cl:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][C:15](=[O:2])[C:16]([O:18][CH2:19][CH3:20])=[O:17]

참가 물질

반응물 4

HCID 712Formaldehyde

HCID 962Water

HCID 1118Sulfuric Acid

HCID 73432769Ethyl 7-chloro-2-hydroxyiminoheptanoate2회

생성물 1

HCID 3018793Ethyl 7-chloro-2-oxoheptanoate

실험 절차

The solution of ethyl 7-chloro-2-hydroxyiminoheptanoate [III-1] in toluene obtained in Example 9 (without being concentrated) is added dropwise into 36 % aqueous formalin solution, and thereto is added sulfuric acid. The mixture is warmed, and further thereto is added water. The organic layer is separated, neutralized, washed with water, and concentrated under reduced pressure to give ethyl 7-chloro-2-oxoheptanoate [I-1].