Chloromethyl Methyl Ether → HCID 19932989, 화합물

HRID 326466노트

반응식

HRID 326466 반응식
C(OC([N:8]1[CH:12]=[C:11]([CH2:13][CH2:14][NH:15][C:16]([O:18][C:19]([CH3:22])([CH3:21])[CH3:20])=[O:17])[N:10]=[CH:9]1)=O)(C)(C)C.[CH3:23][O:24][CH2:25]Cl.C(=O)([O-])O.[Na+]>C(#N)C>[C:19]([O:18][C:16]([NH:15][CH2:14][CH2:13][C:11]1[N:10]([CH2:23][O:24][CH3:25])[CH:9]=[N:8][CH:12]=1)=[O:17])([CH3:20])([CH3:21])[CH3:22]

참가 물질

5

반응물 3

HCID 7864Chloromethyl Methyl EtherHCID 516892Sodium BicarbonateHCID 819122tert-butyl 4-{2-[(tert-butoxycarbonyl)amino]ethyl}-1H-imidazole-1-carboxylate

생성물 1

HCID 19932989HCID 19932989, 화합물수율 84.9%

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

1-t-Butoxycarbonyl-4-{2-(t-butoxycarbonyl-amino)ethyl}imidazole (78.1 g) is dissolved in acetonitrile (500 ml), and thereto is added methoxymethyl chloride (22.2 g), and the mixture is stirred at room temperature overnight. The reaction solution is poured into 10% aqueous sodium hydrogen carbonate solution, and extracted with ethyl acetate. The extract is washed, dried, and the solvent is distilled off to give 4-{2-(t-butoxycarbonyl-amino)ethyl]-3-methoxymethylimidazole (54.4 g) as oil.

후처리

  1. extractionextracted with ethyl acetate
  2. washThe extract is washed
  3. customdried
  4. distillationthe solvent is distilled off

출처 및 근거

ORD 기록
ord-bea66919b5d84a29b23af46ad0ecc4d6
출처 데이터셋
uspto-grants-1993_12
특허 번호
US05268377

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