Morpholine → 2-Morpholino-5-nitrobenzoic acid

HRID 32648

반응식

HRID 32648 반응식
F[C:2]1[CH:10]=[CH:9][C:8]([N+:11]([O-:13])=[O:12])=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].[NH:14]1[CH2:19][CH2:18][O:17][CH2:16][CH2:15]1>O1CCOCC1>[N:14]1([C:2]2[CH:10]=[CH:9][C:8]([N+:11]([O-:13])=[O:12])=[CH:7][C:3]=2[C:4]([OH:6])=[O:5])[CH2:19][CH2:18][O:17][CH2:16][CH2:15]1

참가 물질

4

반응물 2

HCID 8083MorpholineHCID 2809972-Fluoro-5-nitrobenzoic acid

생성물 1

HCID 27257552-Morpholino-5-nitrobenzoic acid수율 93%

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

실험 절차

To a solution of 2-Fluoro-5-nitrobenzoic acid (4.86 g, 26.2 mmol) in dioxane (50 ml) was added morpholine (11.5 ml). The mixture was stirred at room temperature for 2 hours. The solvent was removed in vacuo. The residue was dissolved in water and the mixture was acidified with HCl 2N. The solid was filtered, washed with water and dried to provide the title compound (6.2 g, 93%) as a yellow solid, MS (m/e): 251.2 (M−H, 100%).

후처리

  1. customThe solvent was removed in vacuo
  2. dissolutionThe residue was dissolved in water
  3. filtrationThe solid was filtered
  4. washwashed with water
  5. customdried

출처 및 근거

ORD 기록
ord-2e70c48888a94a1d9855a29162203c8c
출처 데이터셋
uspto-grants-2008_09
특허 번호
US07427612B2

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