Morpholine → 2-Morpholino-5-nitrobenzoic acid
반응식
F[C:2]1[CH:10]=[CH:9][C:8]([N+:11]([O-:13])=[O:12])=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].[NH:14]1[CH2:19][CH2:18][O:17][CH2:16][CH2:15]1>O1CCOCC1>[N:14]1([C:2]2[CH:10]=[CH:9][C:8]([N+:11]([O-:13])=[O:12])=[CH:7][C:3]=2[C:4]([OH:6])=[O:5])[CH2:19][CH2:18][O:17][CH2:16][CH2:15]1참가 물질
4
실험 절차
To a solution of 2-Fluoro-5-nitrobenzoic acid (4.86 g, 26.2 mmol) in dioxane (50 ml) was added morpholine (11.5 ml). The mixture was stirred at room temperature for 2 hours. The solvent was removed in vacuo. The residue was dissolved in water and the mixture was acidified with HCl 2N. The solid was filtered, washed with water and dried to provide the title compound (6.2 g, 93%) as a yellow solid, MS (m/e): 251.2 (M−H, 100%).
후처리
- customThe solvent was removed in vacuo
- dissolutionThe residue was dissolved in water
- filtrationThe solid was filtered
- washwashed with water
- customdried
출처 및 근거
- ORD 기록
- ord-2e70c48888a94a1d9855a29162203c8c
- 출처 데이터셋
- uspto-grants-2008_09
- 특허 번호
- US07427612B2
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