Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Cumene → N-[6-chloro-5-(p-methoxyphenyl)-4-pyrimidinyl]-p-isopropylbenzenesulfonamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Cumene | HCID 7406 | — |
| 반응물 | 4-(Propan-2-yl)benzene-1-sulfonyl chloride | HCID 2734882 | — |
| 반응물 | 4,6-Dichloro-5-(4-methoxyphenyl)pyrimidine | HCID 19735458 | — |
| 반응물 | p-Isopropylbenzenesulfonamide potassium | HCID 67849051 | — |
| 생성물 | N-[6-chloro-5-(p-methoxyphenyl)-4-pyrimidinyl]-p-isopropylbenzenesulfonamide | HCID 19735327 | 57.5% |
반응 단계
p-Isopropylbenzenesulfonyl chloride, boiling point 105° C./0.25 Torr, was prepared from cumene and converted into the corresponding sulfonamide, melting point 104°-105° C. Reaction of 765 mg of 4,6-dichloro-5-(p-methoxyphenyl)-pyrimidine and 925 mg of p-isopropylbenzenesulfonamide potassium yielded 720 mg of N-[6-chloro-5-(p-methoxyphenyl)-4-pyrimidinyl]-p-isopropylbenzenesulfonamide, melting point 181°-182° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05270313 |
| 출처 데이터셋 | uspto-grants-1993_12 |
| ORD ID | ord-2833a550aa704032979e5f70f721a3a7 |
| 출처 메모 | uspto-grants-1993_12 |