Acetaldehyde → HCID 19735971, 화합물

HRID 326780노트

반응식

HRID 326780 반응식
[CH2:1]([O:8][C:9]([C:11]1[CH:19]=[CH:18][C:14]([C:15](Cl)=[O:16])=[CH:13][CH:12]=1)=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH:20](=[O:22])[CH3:21].C(Cl)[Cl:24]>[Cl-].[Zn+2].[Cl-]>[CH2:1]([O:8][C:9]([C:11]1[CH:19]=[CH:18][C:14]([C:15]([O:22][CH:20]([Cl:24])[CH3:21])=[O:16])=[CH:13][CH:12]=1)=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

참가 물질

5

반응물 3

HCID 177AcetaldehydeHCID 6344DichloromethaneHCID 19735978Benzyl 4-(chlorocarbonyl)benzoate

생성물 1

HCID 19735971HCID 19735971, 화합물

시약·촉매·용매 1

HCID 3007855Zincchloride촉매

실험 절차

Zinc chloride (524 mg) was fused in vacuo and, after cooling, treated with 4-(benzyloxycarbonyl)benzoyl chloride (21.48 g, 78.2 mmole). After 30 min., acetaldehyde (3.44 g, 78 mmole) was added at 0° C. The reaction mixture was stirred at room temperature for 30 min. and then diluted with CH2Cl2. The mixture was stirred for another 30 min. and then washed with water (3×). After drying with MgSO4, filtration, and concentration in vacuo, a green/brown solid was obtained that was chromatographed (25:75-CH2Cl2 :hexane) to give 7.65 (31%) of 1-chloroethyl 4-(benzyloxycarbonyl)benzoate as a white solid: mp 79°-82° C.; Anal. calcd for C17H15CIO4 ; C, 64.06; H, 4.74. Found: C, 63.88; H, 4.44. This chloroethyl ester (4.00 g, 12.5 mmole) was combined with the sodium salt of 3-[hydroxy-(2-thienyl)methylene]-6-chloro-5-fluoro- 2,3-dihydro-2-oxo-1H-indole-1-carboxamide (4.51 g, 12.5 mmole) and sodium iodide (644 mg, 4.3 mmole) in acetone (40 ml) and refluxed for 12 hr. The reaction mixture was filtered and the filtrate concentrated in vacuo. The orange/brown gum was chromatographed (25:75-EtOAc: hexane, then 1:99-EtOAc:CH2Cl2) to give 1.947 g (25%) of an orange foam: Anal. calcd. for C31H22ClFN2O7S·2/3H2O: C, 58.81; H, 3.72; N, 4.43. Found: C, 58.74; H, 3.38; N, 4.38.

후처리

  1. temperatureafter cooling
  2. stirringThe mixture was stirred for another 30 min.
  3. washwashed with water (3×)
  4. dry with materialAfter drying with MgSO4, filtration, and concentration in vacuo
  5. customa green/brown solid was obtained
  6. customthat was chromatographed (25:75-CH2Cl2 :hexane)

출처 및 근거

ORD 기록
ord-fb868a24f62e4903924bd4b46ec9733f
출처 데이터셋
uspto-grants-1993_12
특허 번호
US05270331

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