Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
3,5-Dimethylaniline → 4-(2-[2-Trifluoromethylphenyl]acetamido)-2,6-dimethylbenzenesulfonyl chloride
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 3,5-Dimethylaniline | HCID 7949 | — |
| 반응물 | Calcium Carbonate | HCID 10112 | — |
| 반응물 | Chlorosulfonic acid | HCID 24638 | — |
| 반응물 | 2-(Trifluoromethyl)phenylacetyl chloride | HCID 13201823 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | 4-(2-[2-Trifluoromethylphenyl]acetamido)-2,6-dimethylbenzenesulfonyl chloride | HCID 19926639 | 47% |
반응 단계
4-(2-[2-Trifluoromethylphenyl]acetyl)-3,5-dimethylaniline (obtained as a solid, m.p. 168° C., by reacting 2-(2-trifluoromethylphenyl)acetyl chloride with 3,5-dimethylaniline in THF solution in the presence of calcium carbonate) was reacted with an excess of chlorosulfonic acid at 60° C., using an analogous procedure to that described in Organic Synthesis, Coll. Vol. I, at page 85, to give 4-(2-[2-trifluoromethylphenyl]acetamido)-2,6-dimethylbenzenesulfonyl chloride, as a solid in about 47% yield, which was used without purification.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05270342 |
| 출처 데이터셋 | uspto-grants-1993_12 |
| ORD ID | ord-984f32a150834af2bae029f254ed9e16 |
| 출처 메모 | uspto-grants-1993_12 |