4-Piperidone → N-(4-piperidyl)-N'-(2-amino-2-methylpropyl)-1,2-ethanediamine

반응식

[NH2:1][C:2]([CH3:9])([CH3:8])[CH2:3][NH:4][CH2:5][CH2:6][NH2:7].[NH:10]1[CH2:15][CH2:14][C:13](=O)[CH2:12][CH2:11]1>>[NH:10]1[CH2:15][CH2:14][CH:13]([NH:7][CH2:6][CH2:5][NH:4][CH2:3][C:2]([NH2:1])([CH3:9])[CH3:8])[CH2:12][CH2:11]1

참가 물질

반응물 2

HCID 337214-Piperidone

HCID 10898752N,N'-(2-amino-2-methylpropyl)ethylenediamine

생성물 1

HCID 19736233N-(4-piperidyl)-N'-(2-amino-2-methylpropyl)-1,2-ethanediamine

실험 절차

In a manner analogous to that described immediately hereinabove, by reacting N-(2-amino-2-methylpropyl)-1,2-ethanediamine with piperidin-4-one, it is reductively alkylated to yield N-(4-piperidyl)-N'-(2-amino-2-methyl-propyl)-1,2-ethanediamine; and, 2,2,6,6-piperidin-4-one is reductively alkylated to yield N-(2,2,6,6-tetramethyl-4-piperidyl)-N'-(2-amino-2-methylpropyl)-1,2-ethanediamine having the structure: ##STR15##

출처 및 근거

ORD 기록: ord-f60808e2c46e4c61b6f76bcf318f4c83
출처 데이터셋: uspto-grants-1993_12
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US05270471

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