Ammonia → 2-(2,3-Dichlorophenoxy)acetamidine hydrochloride

HRID 326834노트

반응식

HRID 326834 반응식
Cl.[Cl:2][C:3]1[C:15]([Cl:16])=[CH:14][CH:13]=[CH:12][C:4]=1[O:5][CH2:6][C:7](=[NH:11])OCC.[NH3:17]>C(O)C>[ClH:2].[Cl:2][C:3]1[C:15]([Cl:16])=[CH:14][CH:13]=[CH:12][C:4]=1[O:5][CH2:6][C:7]([NH2:11])=[NH:17]

참가 물질

4

반응물 2

HCID 222AmmoniaHCID 19736212Ethyl 2-(2,3-dichlorophenoxy)acetimidate hydrochloride

생성물 1

HCID 197362082-(2,3-Dichlorophenoxy)acetamidine hydrochloride

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

11.8 g (0.041 mole) of ethyl 2-(2,3-dichlorophenoxy)acetimidate hydrochloride are added rapidly to a solution, cooled to 10° C., of 3.5 g (0.21 mole) of ammonia in 100 ml of absolute ethanol. The reaction mixture is left for 3 days at room temperature. After removal of a few suspended particles by filtration, the reaction mixture is concentrated to dryness under reduced pressure. The solid residue obtained is purified by washing with ether and recrystallization from isopropanol. Yld: 8.0 g (75%), m.p. 204.5°-206.5° C.

후처리

  1. customAfter removal of
  2. filtrationby filtration
  3. concentrationthe reaction mixture is concentrated to dryness under reduced pressure
  4. customThe solid residue obtained
  5. customis purified
  6. washby washing with ether and recrystallization from isopropanol

출처 및 근거

ORD 기록
ord-36c2428da5f544928735c639c6d2e630
출처 데이터셋
uspto-grants-1993_12
특허 번호
US05270465

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