2-Phenylmethoxyethanimidamide → 4-Amino-2-(benzyloxymethyl)pteridine

HRID 326838

반응식

HRID 326838 반응식
[NH2:1][C:2]1[C:3]([C:8]#[N:9])=[N:4][CH:5]=[CH:6][N:7]=1.[CH2:10]([O:17][CH2:18][C:19](N)=[NH:20])[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1>C(O)C>[NH2:9][C:8]1[C:3]2[C:2](=[N:7][CH:6]=[CH:5][N:4]=2)[N:1]=[C:19]([CH2:18][O:17][CH2:10][C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[N:20]=1

참가 물질

4

반응물 2

HCID 4164062-PhenylmethoxyethanimidamideHCID 8176993-Aminopyrazine-2-carbonitrile

생성물 1

HCID 107782294-Amino-2-(benzyloxymethyl)pteridine

시약·촉매·용매 1

HCID 702Ethanol용매2회

실험 절차

Obtained using the procedure described in section c of Example 2, starting with 12.0 g )0.10 mole) of 3-amino-2-pyrazinecarbonitrile and 25.0 g (0.15 mole) of 2-(benzyloxy)acetamidine [prepared according to W. J. Haggerty Jr. and W. J. Rost, J. Pharm. Sci. 1969, 58, 50] in 400 ml of absolute ethanol. Refluxing time: 4 hours. Yld: 15.4 g (58%), m.p. 112°-114° C. An analytical sample was obtained by recrystallization from ethanol, followed by washing with dilute hydrochloric acid and finally recrystallization from ethyl acetate. M.p. 131°-133° C.

후처리

  1. customObtained
  2. temperatureRefluxing time
  3. custom4 hours
  4. washby washing with dilute hydrochloric acid and finally recrystallization from ethyl acetate

출처 및 근거

ORD 기록
ord-e8b2a6464fec47e987d82c2a5afa3352
출처 데이터셋
uspto-grants-1993_12
특허 번호
US05270465

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