Morpholine → 5-Cyclopropylmethanesulfonyl-2-morpholin-4-yl-benzoic acid

HRID 32686노트

반응식

HRID 32686 반응식
CS(C1C=CC(N2CCCC2)=C(C=1)C(O)=O)(=O)=O.Cl[C:20]1[CH:28]=[CH:27][C:26]([S:29]([CH2:32][CH:33]2[CH2:35][CH2:34]2)(=[O:31])=[O:30])=[CH:25][C:21]=1[C:22]([OH:24])=[O:23].[NH:36]1[CH2:41][CH2:40][O:39][CH2:38][CH2:37]1>>[CH:33]1([CH2:32][S:29]([C:26]2[CH:27]=[CH:28][C:20]([N:36]3[CH2:41][CH2:40][O:39][CH2:38][CH2:37]3)=[C:21]([CH:25]=2)[C:22]([OH:24])=[O:23])(=[O:31])=[O:30])[CH2:35][CH2:34]1

참가 물질

4

반응물 3

HCID 8083MorpholineHCID 435605642-Chloro-5-cyclopropylmethanesulfonyl-benzoic acidHCID 597934895-Methanesulfonyl-2-pyrrolidin-1-yl-benzoic acid

생성물 1

HCID 597936725-Cyclopropylmethanesulfonyl-2-morpholin-4-yl-benzoic acid수율 27%

실험 절차

The title compound was synthesised according to the procedure described for the synthesis of 5-Methanesulfonyl-2-pyrrolidin-1-yl-benzoic acid from 2-Chloro-5-cyclopropylmethanesulfonyl-benzoic acid and morpholine and obtained in 27% yield. MS (m/e): 324.2 (MH−, 100%).

후처리

  1. customobtained in 27% yield

출처 및 근거

ORD 기록
ord-6c5886eff04649e7aa8245dc627045db
출처 데이터셋
uspto-grants-2008_09
특허 번호
US07427612B2

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