참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | 5-Methylisatoic anhydride | HCID 294478 | — |
| 반응물 | Alanine, methyl ester, hydrochloride (1:1) | HCID 2756298 | — |
| 용매 | Pyridine | HCID 1049 | — |
| 생성물 | 3,4-dihydro-3,7-dimethyl-1H-1,4-benzodiazepine-2,5-dione | HCID 21251942 | 50.5% |
반응 단계
A mixture of 17.7 parts of 6-methyl-4H-3,1-benzoxazine-2,4(1H)-dione, 15.0 parts of methyl 2-aminopropanoate monohydrochloride and 62.7 parts of pyridine was refluxed for 6 hours under argon. The reaction mixture was cooled at -10° C. for 1 hour. The precipitate was filtered off, rinsed with water, triturated in ethanol and rinsed with ethanol and 1,1'-oxybisethane, yielding 10.32 parts (50.5%) of 3,4-dihydro-3,7-dimethyl-1H-1,4-benzodiazepine-2,5-dione (interm. 43).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US05270464 |
|---|
| 출처 데이터셋 | uspto-grants-1993_12 |
|---|
| ORD ID | ord-f7165850443545da827498134458d007 |
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| 출처 메모 | uspto-grants-1993_12 |
|---|
