Diethylamine → Acetoacetamide, N,N-diethyl-
반응식
[CH2:1]([NH:3][CH2:4][CH3:5])[CH3:2].[CH2:6]=[C:7]1[O:11][C:9](=[O:10])[CH2:8]1>C1C=CC=CC=1>[O:11]=[C:7]([CH3:6])[CH2:8][C:9]([N:3]([CH2:4][CH3:5])[CH2:1][CH3:2])=[O:10]참가 물질
4
실험 절차
To a solution of diethylamine (35 g, 0.48 mol) in benzene (75 ml), diketene (40.2 g, 0.48 mol) in benzene (100 ml) was added dropwise at 20°~30° C., stirring was continued for 1 hr. under reflux, and evaporated. The residue (75 g) was chromatographed on silica gel (wako Gel C-200) with dichloromethane/ethyl acetate (10:1) as eluent to give the title compound as a yellow viscous oil; yield: 48.4 g.
후처리
- temperatureunder reflux
- customevaporated
- customThe residue (75 g) was chromatographed on silica gel (wako Gel C-200) with dichloromethane/ethyl acetate (10:1) as eluent
출처 및 근거
- ORD 기록
- ord-6a4aba8c403142e6952616e15519e172
- 출처 데이터셋
- uspto-grants-1993_12
- 특허 번호
- US05272036
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