4-Methylbenzylamine → N-cyano-N'-(4-methylbenzyl)-2-pyridinecarboximidamide

HRID 327091

반응식

HRID 327091 반응식
[C:1]([N:3]=[C:4]([C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][N:8]=1)OC)#[N:2].[CH3:13][C:14]1[CH:21]=[CH:20][C:17]([CH2:18][NH2:19])=[CH:16][CH:15]=1>CO>[C:1]([NH:3][C:4]([C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][N:8]=1)=[N:19][CH2:18][C:17]1[CH:20]=[CH:21][C:14]([CH3:13])=[CH:15][CH:16]=1)#[N:2]

참가 물질

4

반응물 2

HCID 660354-MethylbenzylamineHCID 100121892-Pyridinecarboximidic acid, N-cyano-, methyl ester

생성물 1

HCID 19734553N-cyano-N'-(4-methylbenzyl)-2-pyridinecarboximidamide수율 91%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

Methyl N-cyano-2-pyridinecarboximidate (0.30 g, 1.9 mmol) was dissolved in methanol (10 ml), p-methylbenzylamine (0.25 g, 2.1 mmol) was added, and the resulting mixture was stirred at room temperature for 2 hours. After the reaction was completed, the reaction solution was concentrated under reduced pressure, and the residue thus obtained was crystallized from diethyl ether to give the title compound (0.41 g, 1.6 mmol, yield: 91%) as colorless crystals.

후처리

  1. concentrationthe reaction solution was concentrated under reduced pressure
  2. customthe residue thus obtained
  3. customwas crystallized from diethyl ether

출처 및 근거

ORD 기록
ord-2389de824a604b57bd0ed45a0c64654a
출처 데이터셋
uspto-grants-1993_12
특허 번호
US05272164

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