4-Chlorobenzylamine → N-cyano-N'-(4-chlorobenzyl)-2-pyridinecarboximidamide

HRID 327092노트

반응식

HRID 327092 반응식
[C:1]([N:3]=[C:4]([C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][N:8]=1)OC)#[N:2].[Cl:13][C:14]1[CH:21]=[CH:20][C:17]([CH2:18][NH2:19])=[CH:16][CH:15]=1>CO>[C:1]([NH:3][C:4]([C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][N:8]=1)=[N:19][CH2:18][C:17]1[CH:20]=[CH:21][C:14]([Cl:13])=[CH:15][CH:16]=1)#[N:2]

참가 물질

4

반응물 2

HCID 660364-ChlorobenzylamineHCID 100121892-Pyridinecarboximidic acid, N-cyano-, methyl ester

생성물 1

HCID 19734551N-cyano-N'-(4-chlorobenzyl)-2-pyridinecarboximidamide수율 16.1%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

Methyl N-cyano-2-pyridinecarboximidate (0.50 g, 3.1 mmol) was dissolved in methanol (10 ml), 4-chlorobenzylamine (0.48 g, 3.4 mmol) was added, and the resulting mixture was stirred at room temperature for 5 hours. After the reaction was completed, the reaction solution was concentrated under reduced pressure, and the residue thus obtained was crystallized from diethyl ether to give the title compound (0.13 g, 0.5 mmol, yield: 16%) as colorless crystals.

후처리

  1. concentrationthe reaction solution was concentrated under reduced pressure
  2. customthe residue thus obtained
  3. customwas crystallized from diethyl ether

출처 및 근거

ORD 기록
ord-1bbfd302da1e4f7b950993b809a51943
출처 데이터셋
uspto-grants-1993_12
특허 번호
US05272164

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