1-Bromopentane → 4"-Propyl-4-pentyl-2,3-difluoro-p-terphenyl

HRID 327374노트

반응식

HRID 327374 반응식
C([Li])CCC.[CH2:6]([C:9]1[CH:14]=[CH:13][C:12]([C:15]2[CH:20]=[CH:19][C:18]([C:21]3[CH:26]=[CH:25][CH:24]=[C:23]([F:27])[C:22]=3[F:28])=[CH:17][CH:16]=2)=[CH:11][CH:10]=1)[CH2:7][CH3:8].Br[CH2:30][CH2:31][CH2:32][CH2:33][CH3:34].CC1N(C(N(C)C)=O)C1>CCCCCC.C1COCC1>[CH2:6]([C:9]1[CH:10]=[CH:11][C:12]([C:15]2[CH:20]=[CH:19][C:18]([C:21]3[CH:26]=[CH:25][C:24]([CH2:30][CH2:31][CH2:32][CH2:33][CH3:34])=[C:23]([F:27])[C:22]=3[F:28])=[CH:17][CH:16]=2)=[CH:13][CH:14]=1)[CH2:7][CH3:8]

참가 물질

7

반응물 4

HCID 80571-BromopentaneHCID 11007919N,N,2-trimethylaziridine-1-carboxamideHCID 144957564"-Propyl-2,3-difluoro-p-terphenylHCID 178418339Butyllithium

생성물 1

HCID 144957574"-Propyl-4-pentyl-2,3-difluoro-p-terphenyl

시약·촉매·용매 2

HCID 8028Tetrahydrofuran용매HCID 8058Hexane용매

반응 조건

온도
-100 °C

실험 절차

A solution of n-butyllithium (0.1 mol) in 65 ml of hexane is added to a mixture of 4"-propyl-2,3-difluoro-p-terphenyl (0.1 mol), potassium t-butylate (0.1 mol) and 200 ml of THF at -100° C. After stirring 5 minutes at -100° C. a mixture of brompentane (0.1 mol) and N,N-dimethylpropylene urea (0.1 mol, DMPU) is added. After warming-up to -30° C. and usual work-up 4"-propyl-4-pentyl-2,3-difluoro-p-terphenyl is obtained.

후처리

  1. additionis added
  2. temperatureAfter warming-up to -30° C.

출처 및 근거

ORD 기록
ord-2ebbbf9127644fd9980b56fe1e836f52
출처 데이터셋
uspto-grants-1993_12
특허 번호
US05273680

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