Piperidine → HCID 19108415, 화합물

HRID 327391

반응식

HRID 327391 반응식
[CH2:1]=[C:2]1[C:7](=[O:8])[CH:6]2[CH2:9][CH2:10][N:3]1[CH2:4][CH2:5]2.[NH:11]1[CH2:16][CH2:15][CH2:14][CH2:13][CH2:12]1>CCCCCC>[N:11]1([CH2:1][CH:2]2[C:7](=[O:8])[CH:6]3[CH2:9][CH2:10][N:3]2[CH2:4][CH2:5]3)[CH2:16][CH2:15][CH2:14][CH2:13][CH2:12]1

참가 물질

4

반응물 2

HCID 8082PiperidineHCID 3229732-Methylene-3-quinuclidone

생성물 1

HCID 19108415HCID 19108415, 화합물수율 99.2%

시약·촉매·용매 1

HCID 8058Hexane용매

실험 절차

A reaction flask containing 2-methylenequinuclidin-3-one (6.86 g, 50 mmoles) and a magnetic stir bar was charged with piperidine (12 ml, 120 mmoles). The mixture was stirred at room temperature for 18 hours, and the mixture was added to hexane (300 ml). The solution was filtered through Celite® and the filtrate was concentrated in vacuo (maximum temperature 60° C.) to provide 11.03 g (99%) of the product as a pale yellow solid, mp 34°-37° C.

후처리

  1. filtrationThe solution was filtered through Celite®
  2. concentrationthe filtrate was concentrated in vacuo (maximum temperature 60° C.)

출처 및 근거

ORD 기록
ord-bd0ee1cd5ce24034b39a8c8013ce4fb0
출처 데이터셋
uspto-grants-1993_12
특허 번호
US05273972

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