Oxalyl chloride → 1-Methyl-4-nitro-1H-imidazole-2-carbonyl chloride

HRID 327423노트

반응식

HRID 327423 반응식
[CH3:1][N:2]1[CH:6]=[C:5]([N+:7]([O-:9])=[O:8])[N:4]=[C:3]1[C:10]([OH:12])=O.C(Cl)(=O)C([Cl:16])=O>C1COCC1>[CH3:1][N:2]1[CH:6]=[C:5]([N+:7]([O-:9])=[O:8])[N:4]=[C:3]1[C:10]([Cl:16])=[O:12]

참가 물질

4

반응물 2

HCID 65578Oxalyl chlorideHCID 120679981-Methyl-4-nitro-1H-imidazole-2-carboxylic acid

생성물 1

HCID 191086291-Methyl-4-nitro-1H-imidazole-2-carbonyl chloride

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

To a solution of 1-methyl-4-nitroimidazole-2-carboxylic acid (2.0 g, 0.012 mol) in dry THF (20 mL) was slowly added oxalyl chloride (6 mL). The solution was heated to reflux for 45 minutes, and the solvent and excess oxalyl chloride were removed under reduced pressure to give 1-methyl-4-nitroimidazole-2-carbonyl chloride as a yellow powder which was coevaporated with dry CH2Cl2 (15 mL).

후처리

  1. temperatureThe solution was heated
  2. temperatureto reflux for 45 minutes
  3. customthe solvent and excess oxalyl chloride were removed under reduced pressure

출처 및 근거

ORD 기록
ord-d05f0e15c49f4f5eaa690a306ce1426a
출처 데이터셋
uspto-grants-1993_12
특허 번호
US05273991

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