HCID 19108658, 화합물 → HCID 19108657, 화합물

HRID 327424노트

반응식

HRID 327424 반응식
[CH3:1][N:2]([NH:4][C:5]([C:7]1[N:8]([CH3:15])[CH:9]=[C:10]([N+:12]([O-])=O)[N:11]=1)=[O:6])[CH3:3]>CO.[Pd]>[CH3:3][N:2]([NH:4][C:5]([C:7]1[N:8]([CH3:15])[CH:9]=[C:10]([NH2:12])[N:11]=1)=[O:6])[CH3:1]

참가 물질

4

반응물 1

HCID 19108658HCID 19108658, 화합물

생성물 1

HCID 19108657HCID 19108657, 화합물

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

A suspension of N-(N',N'-dimethylamino)-1-methyl-4-nitroimidazole-2-carboxamide (2.01 g, 9.4 mmol) and 5% Pd on charcoal (0.8 g) in chilled methanol (100 mL) was purged of air and hydrogenated at room temperature and atmospheric pressure for 4 hours. The catalyst was removed by filtration and the solvent was evaporated under reduced pressure to give N-(N',N'-dimethylamino)-1-methyl-4-aminoimidazole-2-carboxamide as a glassy solid which is unstable and used directly in the next step.

후처리

  1. customwas purged of air and hydrogenated at room temperature
  2. customThe catalyst was removed by filtration
  3. customthe solvent was evaporated under reduced pressure

출처 및 근거

ORD 기록
ord-67b5adc0a58f430583acd561c3c1cb17
출처 데이터셋
uspto-grants-1993_12
특허 번호
US05273991

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