Oxalyl chloride → 1-Methyl-4-nitro-1H-imidazole-2-carbonyl chloride

HRID 327427노트

반응식

HRID 327427 반응식
[CH3:1][N:2]1[CH:6]=[C:5]([N+:7]([O-:9])=[O:8])[N:4]=[C:3]1[C:10]([OH:12])=O.C(Cl)(=O)C([Cl:16])=O>C1COCC1>[CH3:1][N:2]1[CH:6]=[C:5]([N+:7]([O-:9])=[O:8])[N:4]=[C:3]1[C:10]([Cl:16])=[O:12]

참가 물질

4

반응물 2

HCID 65578Oxalyl chloride2회HCID 120679981-Methyl-4-nitro-1H-imidazole-2-carboxylic acid

생성물 1

HCID 191086291-Methyl-4-nitro-1H-imidazole-2-carbonyl chloride

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매2회

실험 절차

To a suspension of 1-methyl-4-nitroimidazole-2-carboxylic acid (3.00 g, 17.5 mmol) in dry THF (30 mL) was slowly added oxalyl chloride (12 mL). The reaction mixture was heated to reflux under a drying tube for 45 minutes at which time the excess oxalyl chloride and THF were removed under reduced pressure and the acid chloride coevaporated twice with dry CH2Cl2 (20 mL each) yielding 1-methyl-4-nitroimidazole-2-carbonyl chloride as a yellow powder.

후처리

  1. temperatureThe reaction mixture was heated
  2. customwere removed under reduced pressure

출처 및 근거

ORD 기록
ord-c4c400ae5f8048268425aac0e1979e00
출처 데이터셋
uspto-grants-1993_12
특허 번호
US05273991

반응 노트

불러오는 중…