Formic Acid → 5-Methoxy-4-methylbenzimidazole

HRID 327450노트

반응식

HRID 327450 반응식
[CH3:1][O:2][C:3]1[C:4]([CH3:11])=[C:5]([NH2:10])[C:6]([NH2:9])=[CH:7][CH:8]=1.[CH:12](O)=O>>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]2[NH:9][CH:12]=[N:10][C:5]=2[C:4]=1[CH3:11]

참가 물질

3

반응물 2

HCID 284Formic AcidHCID 5924544-Methoxy-3-methylbenzene-1,2-diamine

생성물 1

HCID 199193885-Methoxy-4-methylbenzimidazole수율 84%

반응 조건

온도
60 °C

실험 절차

A mixture of 4-methoxy-3-methyl-1,2-benzenediamine (2.8 g, 18.4 mmol) and formic acid (30 mL) was heated at 60° C. for 30 minutes. The formic acid was removed under pressure and the product was partitioned between chloroform and water containing sufficient sodium hydroxide to basify the solution. After evaporation of the solvent the crude product was chromatographed (methanol:chloroform) to give 2.55 g (84%) of 5-methoxy-4-methyl-1H-benzimidazole.

후처리

  1. customThe formic acid was removed under pressure
  2. customthe product was partitioned between chloroform and water containing sufficient sodium hydroxide
  3. customAfter evaporation of the solvent the crude product
  4. customwas chromatographed (methanol:chloroform)

출처 및 근거

ORD 기록
ord-fc36aca38dfe4222af2349fc7f21e98b
출처 데이터셋
uspto-grants-1993_12
특허 번호
US05273975

반응 노트

불러오는 중…