6-bromo-1,2,3,4-tetrahydro-8-nitro-N,N-dipropyl-3-quinolinamine → 1,2,3,4-tetrahydro-N3,N3-dipropyl-3,8-quinolinediamine

HRID 327463노트

반응식

HRID 327463 반응식
Br[C:2]1[CH:3]=[C:4]2[C:9](=[C:10]([N+:12]([O-])=O)[CH:11]=1)[NH:8][CH2:7][CH:6]([N:15]([CH2:19][CH2:20][CH3:21])[CH2:16][CH2:17][CH3:18])[CH2:5]2>C(O)C.[Pd]>[CH2:19]([N:15]([CH2:16][CH2:17][CH3:18])[CH:6]1[CH2:5][C:4]2[C:9](=[C:10]([NH2:12])[CH:11]=[CH:2][CH:3]=2)[NH:8][CH2:7]1)[CH2:20][CH3:21]

참가 물질

4

반응물 1

HCID 199194006-bromo-1,2,3,4-tetrahydro-8-nitro-N,N-dipropyl-3-quinolinamine

생성물 1

HCID 152919501,2,3,4-tetrahydro-N3,N3-dipropyl-3,8-quinolinediamine수율 101.3%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 702Ethanol용매

실험 절차

A mixture of 6-bromo-1,2,3,4-tetrahydro-8-nitro-N,N-dipropyl-3-quinolinamine (2.7 g) and 10% palladium charcoal (0.5 g) in ethanol (150 mL) was hydrogenated for 18 hours. The solution was filtered and the ethanol evaporated to give 1.9 g of 1,2,3,4-tetrahydro-N3,N3 -dipropyl-3,8-quinolinediamine as an oil.

후처리

  1. filtrationThe solution was filtered
  2. customthe ethanol evaporated

출처 및 근거

ORD 기록
ord-5096e36bf38d40bdada1cdf61f0a090e
출처 데이터셋
uspto-grants-1993_12
특허 번호
US05273975

반응 노트

불러오는 중…