Chlorosulfonic acid → 5-(Chlorosulfonyl)-2,3-difluorobenzoic acid

HRID 32749

반응식

HRID 32749 반응식
[F:1][C:2]1[C:10]([F:11])=[CH:9][CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].[Cl:12][S:13](O)(=[O:15])=[O:14]>>[Cl:12][S:13]([C:8]1[CH:9]=[C:10]([F:11])[C:2]([F:1])=[C:3]([CH:7]=1)[C:4]([OH:6])=[O:5])(=[O:15])=[O:14]

참가 물질

3

반응물 2

HCID 24638Chlorosulfonic acidHCID 3705902,3-Difluorobenzoic acid

생성물 1

HCID 509984745-(Chlorosulfonyl)-2,3-difluorobenzoic acid

실험 절차

To 2,3-difluoro-benzoic acid (3 g) was added to a solution of chlorosulfonic acid and the reaction mixture was stirred for 2 hours at room temperature. After such time, the reaction mixture was poured onto ice. The resulting solid precipitate was then filtered off and dried in vacuo to yield the title compound as a light grey solid (4.8 g, mp=109-114° C., MS (EI): 256.0 (M+) and was used directly in the next step without any further purification.

후처리

  1. additionAfter such time, the reaction mixture was poured onto ice
  2. filtrationThe resulting solid precipitate was then filtered off
  3. customdried in vacuo

출처 및 근거

ORD 기록
ord-1bd0c94df54c484aad321ce3f5b03f93
출처 데이터셋
uspto-grants-2008_09
특허 번호
US07427612B2

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