Dimethylformamide → 3,4,5-Trimethoxyphenylacetonitrile

HRID 327498

반응식

HRID 327498 반응식
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:8]=[C:9]([O:13][CH3:14])[C:10]=1[O:11][CH3:12])[CH2:6]Cl.[C-]#N.[Na+].[CH3:18][N:19](C)C=O>O>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH2:6][C:18]#[N:19])[CH:8]=[C:9]([O:13][CH3:14])[C:10]=1[O:11][CH3:12]

참가 물질

5

반응물 3

HCID 6228DimethylformamideHCID 8929Sodium CyanideHCID 774485-(Chloromethyl)-1,2,3-trimethoxybenzene

생성물 1

HCID 258873,4,5-Trimethoxyphenylacetonitrile

시약·촉매·용매 1

HCID 962Water용매

반응 조건

온도
80 °C

실험 절차

3,4,5-trimethoxy benzyl chloride 7.0 g and sodium cyanide 6.3 g were dissolved into 50 ml of N,N-dimethylformamide and they were then stirred at 80° C. for 45 minutes. The temperature of the reactive liquid was then lowered down to the room temperature, 200 ml of water was added thereto and then extraction was made thrice by means of 100 ml of ethyl acetate.

후처리

  1. additionwas added
  2. extractionextraction

출처 및 근거

ORD 기록
ord-952544069fad4375a8343463edfcc445
출처 데이터셋
uspto-grants-1993_12
특허 번호
US05273985

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