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Water → 3-[N-Propyl-N-(4-phthalimidobutyl)amino]-5-methoxychroman

HRID 327529
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인쇄 미리보기

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HRID 327529 반응식
[C:1]1(=[O:28])[N:5]([CH2:6][CH2:7][CH2:8][CH2:9][NH:10][CH:11]2[CH2:20][C:19]3[C:14](=[CH:15][CH:16]=[CH:17][C:18]=3[O:21][CH3:22])[O:13][CH2:12]2)[C:4](=[O:23])[C:3]2=[CH:24][CH:25]=[CH:26][CH:27]=[C:2]12.I[CH2:30][CH2:31][CH3:32].C(=O)([O-])[O-].[K+].[K+].O>CN(C)C=O>[CH2:30]([N:10]([CH:11]1[CH2:20][C:19]2[C:14](=[CH:15][CH:16]=[CH:17][C:18]=2[O:21][CH3:22])[O:13][CH2:12]1)[CH2:9][CH2:8][CH2:7][CH2:6][N:5]1[C:4](=[O:23])[C:3]2=[CH:24][CH:25]=[CH:26][CH:27]=[C:2]2[C:1]1=[O:28])[CH2:31][CH3:32]
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참가 물질

6

반응물 4

HCID 962WaterHCID 11430Potassium CarbonateHCID 336431-IodopropaneHCID 104298593-[N-(4-Phthalimidobutyl)amino]-5-methoxychroman

생성물 1

HCID 102516733-[N-Propyl-N-(4-phthalimidobutyl)amino]-5-methoxychroman수율 81%

시약·촉매·용매 1

HCID 6228
Dimethylformamide
용매

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온도
60 °C

실험 절차

1.5 mmol of the compound prepared in Example 1 is dissolved in 10 ml of dimethylformamide in the presence of 4.4 mmol of 1-iodopropane and 4.4 mmol of potassium carbonate. After 24 hours' stirring at 60° C., the solvent is evaporated off and the crude reaction mixture is taken up with 10 ml of water and extracted with dichloromethane. The organic phase is dried and evaporated and the expected product is obtained after purification by chromatography on a silica column (elution solvent: ether/petroleum ether, 1:99).

후처리

  1. customthe solvent is evaporated off
  2. customthe crude reaction mixture
  3. extractionextracted with dichloromethane
  4. customThe organic phase is dried
  5. customevaporated

출처 및 근거

ORD 기록
ord-80248a739c7f4508a5df879234f94340
출처 데이터셋
uspto-grants-1993_12
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US05273994

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