Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Homophthalic anhydride → 2-({3-[(E)-2-(4-Isopropyl-thiazol-2-yl)-vinyl]-phenylcarbamoyl}-methyl)-benzoic acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Homophthalic anhydride | HCID 12801 | — |
| 반응물 | 4-Isopropyl-2-(trans-3-aminostyryl) thiazole | HCID 14051165 | — |
| 용매 | Toluene | HCID 1140 | — |
| 생성물 | 2-({3-[(E)-2-(4-Isopropyl-thiazol-2-yl)-vinyl]-phenylcarbamoyl}-methyl)-benzoic acid | HCID 9844251 | 85.2% |
반응 단계
A mixture of 1.2 g of (E)-3-[2-[4-(1-methylethyl)-2-thiazolyl]ethenyl]benzeneamine, 0.8 g of homophthalic anhydride and 25 ml of toluene was heated to reflux for 0.5 hr. Upon cooling to room temperature, the solid reaction product was filtered and washed with ethyl ether to yield 1.7 g of (E)-2-[2-[3-[2-[4-(1-methylethyl)-2-thiazolyl]ethenyl]phenylamino]-2-oxoethyl]benzoic acid. Recrystallization from ethyl alcohol yielded off-white solid material; m.p. 203°-204° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05273986 |
| 출처 데이터셋 | uspto-grants-1993_12 |
| ORD ID | ord-8d03b41a1581486ab8b8edb1afc61a2d |
| 출처 메모 | uspto-grants-1993_12 |