Homophthalic anhydride → (E)-2-[2-[3-[2-[4-(cyclohexyl)-2-thiazolyl]ethenyl]phenylamino]-2-oxoethyl]benzoic acid

HRID 327551

반응식

HRID 327551 반응식
[CH:1]1([C:7]2[N:8]=[C:9](/[CH:12]=[CH:13]/[C:14]3[CH:15]=[C:16]([NH2:20])[CH:17]=[CH:18][CH:19]=3)[S:10][CH:11]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[C:21]1(=[O:32])[O:27][C:25](=[O:26])[C:24]2=[CH:28][CH:29]=[CH:30][CH:31]=[C:23]2[CH2:22]1>C1(C)C=CC=CC=1>[CH:1]1([C:7]2[N:8]=[C:9](/[CH:12]=[CH:13]/[C:14]3[CH:15]=[C:16]([NH:20][C:21](=[O:32])[CH2:22][C:23]4[CH:31]=[CH:30][CH:29]=[CH:28][C:24]=4[C:25]([OH:27])=[O:26])[CH:17]=[CH:18][CH:19]=3)[S:10][CH:11]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

참가 물질

4

반응물 2

HCID 12801Homophthalic anhydrideHCID 15136084(E)-3-[2-[4-(cyclohexyl)-2-thiazolyl]-ethenyl]benzeneamine

생성물 1

HCID 20084320(E)-2-[2-[3-[2-[4-(cyclohexyl)-2-thiazolyl]ethenyl]phenylamino]-2-oxoethyl]benzoic acid수율 93.7%

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

A solution of 2.8 g of (E)-3-[2-[4-(cyclohexyl)-2-thiazolyl]ethenyl]benzeneamine, 1.78 g of homophthalic anhydride and 30 ml of toluene were heated to reflux for 0.5 hr. Cooling and filtration yielded 4.12 g of (E)-2-[2-[3-[2-[4-(cyclohexyl)-2-thiazolyl]ethenyl]phenylamino]-2-oxoethyl]benzoic acid; m.p. 210°-211° C. from tetrahydrofuran.

후처리

  1. temperatureto reflux for 0.5 hr
  2. temperatureCooling
  3. filtrationfiltration

출처 및 근거

ORD 기록
ord-983aa1a123024550bfc9ac0b27d9fee6
출처 데이터셋
uspto-grants-1993_12
특허 번호
US05273986

연결된 노트

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