Bromine → 2-Bromo-1-cycloheptylethan-1-one

HRID 327552노트

반응식

HRID 327552 반응식
[CH3:1][C:2]([CH:4]1[CH2:10][CH2:9][CH2:8][CH2:7][CH2:6][CH2:5]1)=[O:3].[Br:11]Br>CO>[CH:4]1([C:2]([CH2:1][Br:11])=[O:3])[CH2:10][CH2:9][CH2:8][CH2:7][CH2:6][CH2:5]1

참가 물질

4

반응물 2

HCID 24408BromineHCID 126763521-Cycloheptylethan-1-one

생성물 1

HCID 218423502-Bromo-1-cycloheptylethan-1-one

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

An ice cold solution of 19.0 g of cycloheptyl methyl ketone in 100 ml of methyl alcohol was treated dropwise with 7 ml of bromine. After 5 min, the ice bath was removed and the reaction mixture was allowed to warm to room temperature. The reaction mixture was then diluted with 500 ml of water and extracted with ethyl ether (3×75 ml). The combined extracts were washed with saturated sodium bicarbonate, brine, dried (MgSO4) and condensed in vacuo to yield 29.9 g of bromomethyl cycloheptyl ketone as an oil.

후처리

  1. customthe ice bath was removed
  2. additionThe reaction mixture was then diluted with 500 ml of water
  3. extractionextracted with ethyl ether (3×75 ml)
  4. washThe combined extracts were washed with saturated sodium bicarbonate, brine
  5. customdried
  6. custom(MgSO4) and condensed in vacuo

출처 및 근거

ORD 기록
ord-a964acab60494a909aa1a4bce5671ee9
출처 데이터셋
uspto-grants-1993_12
특허 번호
US05273986

반응 노트

불러오는 중…