1-(4-(Trifluoromethyl)phenyl)piperazine → (2-Iodo-5-methanesulfonyl-phenyl)-[4-(4-trifluoromethyl-phenyl)-piperazin-1-yl]-methanone

HRID 32757

반응식

HRID 32757 반응식
[I:1][C:2]1[CH:10]=[CH:9][C:8]([S:11]([CH3:14])(=[O:13])=[O:12])=[CH:7][C:3]=1[C:4]([OH:6])=O.[F:15][C:16]([F:30])([F:29])[C:17]1[CH:22]=[CH:21][C:20]([N:23]2[CH2:28][CH2:27][NH:26][CH2:25][CH2:24]2)=[CH:19][CH:18]=1>>[I:1][C:2]1[CH:10]=[CH:9][C:8]([S:11]([CH3:14])(=[O:13])=[O:12])=[CH:7][C:3]=1[C:4]([N:26]1[CH2:25][CH2:24][N:23]([C:20]2[CH:19]=[CH:18][C:17]([C:16]([F:29])([F:30])[F:15])=[CH:22][CH:21]=2)[CH2:28][CH2:27]1)=[O:6]

참가 물질

3

반응물 2

HCID 1217181-(4-(Trifluoromethyl)phenyl)piperazineHCID 574452812-Iodo-5-methanesulfonyl-benzoic acid

생성물 1

HCID 59793691(2-Iodo-5-methanesulfonyl-phenyl)-[4-(4-trifluoromethyl-phenyl)-piperazin-1-yl]-methanone

실험 절차

Example CK was prepared in analogy to Example 123 from 2-Iodo-5-methanesulfonyl-benzoic acid (example BQ) and 1-(4-Trifluoromethyl-phenyl)-piperazine (commercial). MS (m/e): 539.1 (M+H+, 100%).

출처 및 근거

ORD 기록
ord-c4e428a71fbd426e8aa610d2e5d1605a
출처 데이터셋
uspto-grants-2008_09
특허 번호
US07427612B2

연결된 노트

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