3-Fluoro-4-piperazin-1-yl-benzonitrile → 3-Fluoro4-[4-(2-iodo-5-methanesulfonyl-benzoyl)-piperazin-1-yl]-benzonitrile

HRID 32758노트

반응식

HRID 32758 반응식
[I:1][C:2]1[CH:10]=[CH:9][C:8]([S:11]([CH3:14])(=[O:13])=[O:12])=[CH:7][C:3]=1[C:4]([OH:6])=O.[F:15][C:16]1[CH:17]=[C:18]([CH:21]=[CH:22][C:23]=1[N:24]1[CH2:29][CH2:28][NH:27][CH2:26][CH2:25]1)[C:19]#[N:20]>>[F:15][C:16]1[CH:17]=[C:18]([CH:21]=[CH:22][C:23]=1[N:24]1[CH2:29][CH2:28][N:27]([C:4](=[O:6])[C:3]2[CH:7]=[C:8]([S:11]([CH3:14])(=[O:13])=[O:12])[CH:9]=[CH:10][C:2]=2[I:1])[CH2:26][CH2:25]1)[C:19]#[N:20]

참가 물질

3

반응물 2

HCID 5961133-Fluoro-4-piperazin-1-yl-benzonitrileHCID 574452812-Iodo-5-methanesulfonyl-benzoic acid

생성물 1

HCID 597935053-Fluoro4-[4-(2-iodo-5-methanesulfonyl-benzoyl)-piperazin-1-yl]-benzonitrile

실험 절차

Example CL was prepared in analogy to Example 123 from 2-Iodo-5-methanesulfonyl-benzoic acid (example BQ) and 3-Fluoro-4-piperazin-1-yl-benzonitrile (WO9625414). MS (m/e): 514.0 (M+H+, 100%).

출처 및 근거

ORD 기록
ord-993dced8c83348ca91f3b6df02c8c962
출처 데이터셋
uspto-grants-2008_09
특허 번호
US07427612B2

반응 노트

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