Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Tris(hydroxymethyl)aminomethane → (E)-2-[2-[3-[2-[4-(cyclobutyl)-2-thiazolyl]ethenyl]phenylamino]-2-oxoethyl]benzoic acid tris-(hydroxymethyl)-amino-methane salt
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Tris(hydroxymethyl)aminomethane | HCID 6503 | — |
| 반응물 | (E)-2-[2-[3-[2-[4-(cyclobutyl)-2-thiazolyl]ethenyl]phenylamino]-2-oxoethyl]benzoic acid | HCID 20084337 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | (E)-2-[2-[3-[2-[4-(cyclobutyl)-2-thiazolyl]ethenyl]phenylamino]-2-oxoethyl]benzoic acid tris-(hydroxymethyl)-amino-methane salt | HCID 67807895 | — |
반응 단계
A mixture of 0.418 g of (E)-2-[2-[3-[2-[4-(cyclobutyl)-2-thiazolyl]ethenyl]phenylamino]-2-oxoethyl]benzoic acid and 0.1214 g of tris-(hydroxymethyl)-amino-methane were solubilized in 10 ml of ethyl alcohol with warming on a steam bath until all the solids had solubilized. After cooling the reaction mixture was condensed in vacuo at 40° C. to constant weight to yield (E)-2-[2-[3-[2-[4-(cyclobutyl)-2-thiazolyl]ethenyl]phenylamino]-2-oxoethyl]benzoic acid tris-(hydroxymethyl)-amino-methane salt as a white solid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05273986 |
| 출처 데이터셋 | uspto-grants-1993_12 |
| ORD ID | ord-95ccb0ee5527426282d02c9dc2f3e94e |
| 출처 메모 | uspto-grants-1993_12 |