Phenoxyacetic Acid → (+)-1,2,3,4-tetrahydro-5-methoxy-N-[-2[(2,5-dimethyl)phenoxy]ethyl]-N-propyl-2-naphthalenamine

HRID 327591

반응식

HRID 327591 반응식
O(CC(O)=O)C1C=CC=CC=1.[CH3:12][C:13]1[CH:23]=[CH:22][C:21]([CH3:24])=[CH:20][C:14]=1[O:15][CH2:16][C:17](O)=O.[CH2:25]([NH:28][CH:29]1[CH2:38][CH2:37][C:36]2[C:31](=[CH:32][CH:33]=[CH:34][C:35]=2[O:39][CH3:40])[CH2:30]1)[CH2:26][CH3:27]>>[CH3:40][O:39][C:35]1[CH:34]=[CH:33][CH:32]=[C:31]2[C:36]=1[CH2:37][CH2:38][CH:29]([N:28]([CH2:17][CH2:16][O:15][C:14]1[CH:20]=[C:21]([CH3:24])[CH:22]=[CH:23][C:13]=1[CH3:12])[CH2:25][CH2:26][CH3:27])[CH2:30]2

참가 물질

4

반응물 3

HCID 19188Phenoxyacetic AcidHCID 818172,5-Xylyloxyacetic acidHCID 102425482-Propylamino-5-methoxytetralin2회

생성물 1

HCID 19926555(+)-1,2,3,4-tetrahydro-5-methoxy-N-[-2[(2,5-dimethyl)phenoxy]ethyl]-N-propyl-2-naphthalenamine

실험 절차

In Example 29, phenoxyacetic acid was replaced by 2,5-dimethylphenoxyacetic acid and (-)-2-(N-n-propylamino)-5-methoxytetralin was replaced by (+)-2-(N-n-propylamino)-5-methoxytetralin. The crude mixture was subjected to flash chromatography (Silica: 9:1 pet ether/EtOAc) and the product showed characteristic peaks at: NMR (300 MHz, CDCl3) δ 7.1-6.6(m, 6H), 4.0(t, 2H), 3.8(s, 3H), 2.3(s, 3H), 2.15(s, 3H), 0.9(t,3H).

출처 및 근거

ORD 기록
ord-1c93cd1dd537403aa99da155120c6798
출처 데이터셋
uspto-grants-1993_12
특허 번호
US05274003

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