Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
7-Chloro-3-methyl-1-phenyl-1,2,4,5-tetrahydro-3-benzazepin-8-ol → Dopamine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 7-Chloro-3-methyl-1-phenyl-1,2,4,5-tetrahydro-3-benzazepin-8-ol | HCID 5018 | — |
| 반응물 | Spiperone | HCID 5265 | — |
| 반응물 | (+)-Butaclamol | HCID 37459 | — |
| 반응물 | R-(+)-8-chloro-2,3,4,5-tetrahydro-3-methyl-5-phenyl-1H-3-benzazepine-7-ol | HCID 3036864 | — |
| 생성물 | Dopamine | HCID 681 | — |
반응 단계
The following tritiated drugs were used as radioligands for each of the receptors tested: [3H]-Spiperone 21-24 Ci/mmol for D2 receptors and [3H]-SCH23390 75-85 Ci/mmol for D1 receptors. The radioligands were incubated with various concentrations of competing drug and the appropriate membrane source for periods of time as follows: 75 minutes at room temperature for D2 receptors or 15 minutes at 37° C. for D1 receptors. Specific binding was defined using 1 μM butaclamol (D2) or 1 μM SCH23390 (D1). In addition, the D2 assays contained 30 nM ketaserin in order to block the binding of 3H-spiperone to 5HT2 receptors.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05274003 |
| 출처 데이터셋 | uspto-grants-1993_12 |
| ORD ID | ord-5ce47448ae38482fa84af9f96e6a1620 |
| 출처 메모 | uspto-grants-1993_12 |