1-(2-Fluoro-4-(trifluoromethyl)phenyl)piperazine → [4-(2-Fluoro-4-trifluoromethyl-phenyl)piperazin-1-yl]-(2-iodo-5-methanesulfonyl-phenyl)-methanone

HRID 32760노트

반응식

HRID 32760 반응식
[I:1][C:2]1[CH:10]=[CH:9][C:8]([S:11]([CH3:14])(=[O:13])=[O:12])=[CH:7][C:3]=1[C:4]([OH:6])=O.[F:15][C:16]1[CH:21]=[C:20]([C:22]([F:25])([F:24])[F:23])[CH:19]=[CH:18][C:17]=1[N:26]1[CH2:31][CH2:30][NH:29][CH2:28][CH2:27]1>>[F:15][C:16]1[CH:21]=[C:20]([C:22]([F:23])([F:24])[F:25])[CH:19]=[CH:18][C:17]=1[N:26]1[CH2:31][CH2:30][N:29]([C:4]([C:3]2[CH:7]=[C:8]([S:11]([CH3:14])(=[O:13])=[O:12])[CH:9]=[CH:10][C:2]=2[I:1])=[O:6])[CH2:28][CH2:27]1

참가 물질

3

반응물 2

HCID 468374951-(2-Fluoro-4-(trifluoromethyl)phenyl)piperazineHCID 574452812-Iodo-5-methanesulfonyl-benzoic acid

생성물 1

HCID 59793591[4-(2-Fluoro-4-trifluoromethyl-phenyl)piperazin-1-yl]-(2-iodo-5-methanesulfonyl-phenyl)-methanone

실험 절차

Example CN was prepared in analogy to Example 123 from 2-Iodo-5-methanesulfonyl-benzoic acid (example BQ) and 1-(2-Fluoro-4-trifluoromethyl-phenyl)-piperazine (example H). MS (m/e): 574.2 (M+NH4+, 100%).

출처 및 근거

ORD 기록
ord-6b34ea0078004e6c810dbecb95356285
출처 데이터셋
uspto-grants-2008_09
특허 번호
US07427612B2

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