Tetrahydrofurfurylamine → Rac-{5-methanesulfonyl-2-[(tetrahydro-furan-2-ylmethyl)-amino]-phenyl}-[4-(4-trifluoromethyl-phenyl)-piperazin-1-yl]-methanone

HRID 32772

반응식

I[C:2]1[CH:7]=[CH:6][C:5]([S:8]([CH3:11])(=[O:10])=[O:9])=[CH:4][C:3]=1[C:12]([N:14]1[CH2:19][CH2:18][N:17]([C:20]2[CH:25]=[CH:24][C:23]([C:26]([F:29])([F:28])[F:27])=[CH:22][CH:21]=2)[CH2:16][CH2:15]1)=[O:13].[CH2:30]([NH2:36])[CH:31]1[O:35][CH2:34][CH2:33][CH2:32]1>>[CH3:11][S:8]([C:5]1[CH:6]=[CH:7][C:2]([NH:36][CH2:30][CH:31]2[CH2:32][CH2:33][CH2:34][O:35]2)=[C:3]([C:12]([N:14]2[CH2:19][CH2:18][N:17]([C:20]3[CH:25]=[CH:24][C:23]([C:26]([F:29])([F:28])[F:27])=[CH:22][CH:21]=3)[CH2:16][CH2:15]2)=[O:13])[CH:4]=1)(=[O:10])=[O:9]

참가 물질

반응물 2

HCID 253298Tetrahydrofurfurylamine

HCID 59793691(2-Iodo-5-methanesulfonyl-phenyl)-[4-(4-trifluoromethyl-phenyl)-piperazin-1-yl]-methanone

생성물 1

HCID 68840286Rac-{5-methanesulfonyl-2-[(tetrahydro-furan-2-ylmethyl)-amino]-phenyl}-[4-(4-trifluoromethyl-phenyl)-piperazin-1-yl]-methanone수율 28%

실험 절차

The title compound was prepared according to the procedure described for example 301 from (2-Iodo-5-methanesulfonyl-phenyl)-[4-(4-trifluoromethyl-phenyl)-piperazin-1-yl]-methanone (compound CK) and tetrahydrofurfurylamine (28% yield, MS (m/e): 512.4 (M+H, 100%)

출처 및 근거

ORD 기록: ord-727a90b700ff46f2bf415063161642eb
출처 데이터셋: uspto-grants-2008_09
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07427612B2

연결된 노트

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