tert-Butyl piperazine-1-carboxylate → tert-Butyl 4-[2-(trifluoromethyl)pyrimidin-5-yl]piperazine-1-carboxylate

HRID 32774

반응식

HRID 32774 반응식
Cl[C:2]1[CH:3]=[N:4][C:5]([C:8]([F:11])([F:10])[F:9])=[N:6][CH:7]=1.[C:12]([O:16][C:17]([N:19]1[CH2:24][CH2:23][NH:22][CH2:21][CH2:20]1)=[O:18])([CH3:15])([CH3:14])[CH3:13]>CC(N(C)C)=O>[C:12]([O:16][C:17]([N:19]1[CH2:24][CH2:23][N:22]([C:2]2[CH:3]=[N:4][C:5]([C:8]([F:11])([F:10])[F:9])=[N:6][CH:7]=2)[CH2:21][CH2:20]1)=[O:18])([CH3:15])([CH3:13])[CH3:14]

참가 물질

4

반응물 2

HCID 143452tert-Butyl piperazine-1-carboxylateHCID 336979605-Chloro-2-(trifluoromethyl)pyrimidine

생성물 1

HCID 53485514tert-Butyl 4-[2-(trifluoromethyl)pyrimidin-5-yl]piperazine-1-carboxylate

시약·촉매·용매 1

HCID 31374Dimethylacetamide용매

반응 조건

온도
150 °C

실험 절차

0.26 mmol 5-Chloro-2-trifluoromethyl-pyrimidine was added to 0.26 mmol piperazine-1-carboxylic acid tert-butyl ester in 1.5 ml dimethylacetamide and the reaction mixture was stirred at 150° C. for 10 min. in a microwave oven. After such time the reaction mixture was concentrated and the residue was then purified by column chromatography (SiO2, Heptane/EtOAc) to yield the title compound. MS (m/e): 333.2 (M+H+, 100%)

후처리

  1. concentrationAfter such time the reaction mixture was concentrated
  2. customthe residue was then purified by column chromatography (SiO2, Heptane/EtOAc)

출처 및 근거

ORD 기록
ord-7b87cda084cb4295a0c9363f74a23479
출처 데이터셋
uspto-grants-2008_09
특허 번호
US07427612B2

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