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Acetonitrile → Tert-butyl 4-(4-chloro-1,3,5-triazin-2-yl)piperazine-1-carboxylate

HRID 32775
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인쇄 미리보기

반응식

HRID 32775 반응식
ClN1[N:7]=[C:6]([Cl:8])C=CN1.[CH2:9]([N:11]([CH2:14]C)CC)C.[C:16]([N:23]1[CH2:28][CH2:27][NH:26][CH2:25][CH2:24]1)([O:18][C:19]([CH3:22])([CH3:21])[CH3:20])=[O:17].C(OCC)(=O)C.C(#[N:37])C>[Cl-].[Na+].O>[C:19]([O:18][C:16]([N:23]1[CH2:24][CH2:25][N:26]([C:9]2[N:7]=[C:6]([Cl:8])[N:37]=[CH:14][N:11]=2)[CH2:27][CH2:28]1)=[O:17])([CH3:22])([CH3:21])[CH3:20]
참가 물질반응 조건실험 절차후처리출처 및 근거반응 노트

참가 물질

7

반응물 5

HCID 6342AcetonitrileHCID 8471TriethylamineHCID 8857Ethyl AcetateHCID 143452tert-Butyl piperazine-1-carboxylateHCID 178478418HCID 178478418, 화합물

생성물 1

HCID 86600711Tert-butyl 4-(4-chloro-1,3,5-triazin-2-yl)piperazine-1-carboxylate

시약·촉매·용매 1

HCID 57417360
Sodium chloride; water
용매

반응 조건

온도
0 °C

실험 절차

A solution of 11 mmol of 2,4-dichlorotriazine (WO 02/083654) in 20 ml of acetonitrile was chilled and treated with 11 mmol of triethylamine and 11 mmol of N-BOC-piperazine. The reaction mixture was stirred for 2 hours at 0° C. then for 2 hours at room temperature. Addition of 100 ml brine and extraction with ethyl acetate yielded the crude product which was purified through trituration in ethyl acetate. MS (m/e): 300.3 (MH+, 100%)

후처리

  1. waitfor 2 hours at room temperature

출처 및 근거

ORD 기록
ord-fdd7a5d52699420ba2d429cc91c66bbc
출처 데이터셋
uspto-grants-2008_09
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US07427612B2

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