2-Chloroethyl isocyanate → N-(6-Bromo-2-pyridinyl)-N'-(2-chloroethyl)urea
반응식
[Br:1][C:2]1[N:7]=[C:6]([NH2:8])[CH:5]=[CH:4][CH:3]=1.[Cl:9][CH2:10][CH2:11][N:12]=[C:13]=[O:14]>C1COCC1>[Br:1][C:2]1[N:7]=[C:6]([NH:8][C:13]([NH:12][CH2:11][CH2:10][Cl:9])=[O:14])[CH:5]=[CH:4][CH:3]=1참가 물질
4
실험 절차
To a solution of 6-bromo-2-pyridinamine (1 g, 5.78 mmol) in anh. THF (25 mL), at r.t., under N2, was added 1-chloro-2-isocyanatoethane (1.2 mL, 2.5 eq) and the reaction mixture was stirred at r.t. for 18 hr. The crude mixture was partitioned between CH2Cl2 and water. The phases were separated and the organic layer was dried over anh. Na2SO4. The solids were filtered and the solvent evaporated to give the title compound (1.06 g, 66%) which was used in the next step without further purification.
후처리
- customThe crude mixture was partitioned between CH2Cl2 and water
- customThe phases were separated
- dry with materialthe organic layer was dried over anh. Na2SO4
- filtrationThe solids were filtered
- customthe solvent evaporated
출처 및 근거
- ORD 기록
- ord-a57cf86785af40228e02713709f17dc7
- 출처 데이터셋
- uspto-grants-2008_09
- 특허 번호
- US07427630B2
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