Ammonium Hydroxide → 1-(2-Amino-1,3-thiazol-4-yl)ethan-1-one

HRID 32804노트

반응식

HRID 32804 반응식
Cl.[NH2:2][C:3]1[S:4][CH:5]=[C:6]([C:8](=[O:10])[CH3:9])[N:7]=1.[OH-].[NH4+]>O>[NH2:2][C:3]1[S:4][CH:5]=[C:6]([C:8](=[O:10])[CH3:9])[N:7]=1

참가 물질

4

반응물 2

HCID 14923Ammonium HydroxideHCID 50998257HCID 50998257, 화합물

생성물 1

HCID 31119641-(2-Amino-1,3-thiazol-4-yl)ethan-1-one수율 62.8%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

1-(2-Amino-thiazol-4-yl)-ethanone hydrochloride (5.6 g 29.1 mmol) was dissolved in water (15 mL) and cooled in an ice bath. To this was added dropwise 17 N ammonium hydroxide (15 mL, 105 mmol). The resulting mixture was stirred for 15 minutes than filtered and washed with cold water (3×), cold methanol (3×50 mL), ethyl ether (3×10 mL). The precipitate was dried first by passing air through the material and then in vacuo to give 1-(2-amino-thiazol-4-yl)-ethanone as a pale yellow solid (2.6 g, 57%).

후처리

  1. temperaturecooled in an ice bath
  2. filtrationthan filtered
  3. washwashed with cold water (3×), cold methanol (3×50 mL), ethyl ether (3×10 mL)
  4. customThe precipitate was dried first

출처 및 근거

ORD 기록
ord-20db3dd31de543458c8215a5f7af857c
출처 데이터셋
uspto-grants-2008_09
특허 번호
US07427635B2

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