Thionyl Chloride → HCID 21443926, 화합물
반응식
[C:1]([C:4]1[CH:9]=[CH:8][C:7]([CH2:10][C:11]([OH:13])=O)=[CH:6][CH:5]=1)(=[NH:3])[NH2:2].S(Cl)([Cl:16])=O>C1C=CC=CC=1.CN(C)C=O>[ClH:16].[C:1]([C:4]1[CH:9]=[CH:8][C:7]([CH2:10][C:11]([Cl:16])=[O:13])=[CH:6][CH:5]=1)(=[NH:3])[NH2:2]참가 물질
5
실험 절차
5.35 g of 4-amidinophenylacetic acid (M.p. 295° to 297° C, decomposition) were suspended in 45 ml of anhydrous benzene. Two drops of dimethylformamide and 17.9 g of thionyl chloride were added and the whole was heated for 11/2 hours under reflux. After cooling, the solid product was filtered off with suction, washed with anhydrous benzene and dried under reduced pressure. 6.9 g of 4-amidino-phenylacetyl chloride-hydrochloride melting at 174° to 177° C (decomposition) were obtained.
후처리
- temperaturethe whole was heated for 11/2 hours
- temperatureunder reflux
- temperatureAfter cooling
- filtrationthe solid product was filtered off with suction
- washwashed with anhydrous benzene
- customdried under reduced pressure
출처 및 근거
- ORD 기록
- ord-d93d65c20ae7453291def8277cf8f509
- 출처 데이터셋
- uspto-grants-1977_04
- 특허 번호
- US04016159
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