Thionyl Chloride → HCID 178479372, 화합물

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[NH:1]([C:5]1[CH:10]=[CH:9][C:8]([CH2:11][C:12]([OH:14])=O)=[CH:7][CH:6]=1)[C:2]([NH2:4])=[NH:3].S(Cl)([Cl:17])=O>>[ClH:17].[NH:1]([C:5]1[CH:10]=[CH:9][C:8]([CH2:11][C:12]([Cl:17])=[O:14])=[CH:7][CH:6]=1)[C:2]([NH2:4])=[NH:3]

참가 물질

반응물 2

HCID 24386Thionyl Chloride

HCID 178512496HCID 178512496, 화합물

생성물 1

HCID 178479372HCID 178479372, 화합물

반응 조건

온도: 0 °C

실험 절차

21 g of 4-guanidino-phenylacetic acid were added to 200 ml of thionyl chloride that had been cooled to 0° C. After 15 minutes at 0° C, the whole was stirred for 15 minutes at room temperature, the product as precipitated with 500 ml of anhydrous ether, filtered off with suction, washed with anhydrous ether and dried under reduced pressure. 24.7 g of 4-guanidino-phenylacetyl chloride hydrochloride melting at 127° to 130° C were obtained.

후처리

customthe product as precipitated with 500 ml of anhydrous ether
filtrationfiltered off with suction
washwashed with anhydrous ether
customdried under reduced pressure

출처 및 근거

ORD 기록: ord-e2786caefb934e4e9c5785a27b2238f4
출처 데이터셋: uspto-grants-1977_04
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04016159

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