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Water → HCID 70637164, 화합물

HRID 328137
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HRID 328137 반응식
S(OC1CCN2C3C=CC=CC=3CC3C=CC=CC=3C2C1)(C1C=CC(C)=CC=1)(=O)=O.[C:31]([CH:33]1[CH2:51][CH2:50][N:36]2[C:37]3[CH:49]=[CH:48][CH:47]=[CH:46][C:38]=3[CH2:39][C:40]3[CH:45]=[CH:44][CH:43]=[CH:42][C:41]=3[CH:35]2[CH2:34]1)#[N:32].O>CCOCC.C1COCC1>[NH2:32][CH2:31][CH:33]1[CH2:51][CH2:50][N:36]2[C:37]3[CH:49]=[CH:48][CH:47]=[CH:46][C:38]=3[CH2:39][C:40]3[CH:45]=[CH:44][CH:43]=[CH:42][C:41]=3[CH:35]2[CH2:34]1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

6

반응물 3

HCID 962WaterHCID 70637584HCID 70637584, 화합물HCID 86734600HCID 86734600, 화합물2회

생성물 1

HCID 70637164HCID 70637164, 화합물

시약·촉매·용매 2

HCID 3283Diethyl Ether용매HCID 8028Tetrahydrofuran용매

실험 절차

To a suspension of 10 g LiAlH 4 in 400 ml of dry ether a solution of 8 g of 2-cyano-1,2,3,4,10,14b-hexahydro-pyridino [1,2-a]-dibenzo[c,f]-azepine (axial) in 300 ml of THF is added. Then the mixture is refluxed for 30 minutes, whereupon it is cooled by means of ice. After that 40 ml of water are added to the mixture carefully so as to hydrolyse the excess of LiAlH 4. The resulting precipitate is filtered off after which the filtrate is evaporated.

후처리

  1. additionis added
  2. temperatureThen the mixture is refluxed for 30 minutes, whereupon it
  3. temperatureis cooled by means of ice
  4. filtrationThe resulting precipitate is filtered off after which the filtrate
  5. customis evaporated

출처 및 근거

ORD 기록
ord-519a16c179b34475b56f2ed6279884a3
출처 데이터셋
uspto-grants-1977_04
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US04016161

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