Furo(3,4-b)pyrazine-5,7-dione → (1-Ethyl-2-methylindol-3-yl)-(2-carboxypyrazin-3-yl)ketone

HRID 328145

반응식

HRID 328145 반응식
[N:1]1[CH:6]=[CH:5][N:4]=[C:3]2[C:7]([O:9][C:10](=[O:11])[C:2]=12)=[O:8].[CH2:12]([N:14]1[C:22]2[C:17](=[CH:18][CH:19]=[C:20]3C=CC=C[C:21]3=2)[CH:16]=[C:15]1[CH3:27])[CH3:13]>>[CH2:12]([N:14]1[C:22]2[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=2)[C:16]([C:7]([C:3]2[C:2]([C:10]([OH:9])=[O:11])=[N:1][CH:6]=[CH:5][N:4]=2)=[O:8])=[C:15]1[CH3:27])[CH3:13]

참가 물질

3

반응물 2

HCID 78482Furo(3,4-b)pyrazine-5,7-dioneHCID 151143961-Ethyl-2-methyl-1H-benzo[G]indole

생성물 1

HCID 20534320(1-Ethyl-2-methylindol-3-yl)-(2-carboxypyrazin-3-yl)ketone수율 16.2%

실험 절차

The appropriate keto-acid is prepared as follows. A mixture of about 6 grams of 2,3-pyrazinedicarboxylic anhydride and about 10.5 grams of 1-ethyl-2-methyl-1H-benz[g]indole is heated on a steam bath for about 24 hours. The mixture is extracted with toluene. About 2 grams of (1-ethyl-2-methylindol-3-yl)-(2-carboxypyrazin-3-yl)ketone is obtained having a melting point of 212°-213° C.

후처리

  1. temperatureis heated on a steam bath for about 24 hours
  2. extractionThe mixture is extracted with toluene

출처 및 근거

ORD 기록
ord-0f984a2661954e6489dd9836d234c9c2
출처 데이터셋
uspto-grants-1977_04
특허 번호
US04016174

연결된 노트

불러오는 중…