Pyridine → ZR 2646

HRID 328152노트

반응식

HRID 328152 반응식
N1C=CC=CC=1.[C:7](Cl)(=[O:12])[C:8]([CH3:11])([CH3:10])[CH3:9].Cl.N1C=CC=CC=1.[CH2:21]([O:23][C:24]([C:26]1[CH:37]=[CH:36][C:29]([O:30][CH2:31][CH:32]([OH:35])[CH2:33][CH3:34])=[CH:28][CH:27]=1)=[O:25])[CH3:22]>>[C:7]([O:35][CH:32]([CH2:33][CH3:34])[CH2:31][O:30][C:29]1[CH:36]=[CH:37][C:26]([C:24]([O:23][CH2:21][CH3:22])=[O:25])=[CH:27][CH:28]=1)(=[O:12])[C:8]([CH3:11])([CH3:10])[CH3:9]

참가 물질

5

반응물 4

HCID 1049PyridineHCID 62493Pivaloyl chlorideHCID 10176127Pyridinium chlorideHCID 21444117Ethyl 4-(2-hydroxybutoxy)benzoate

생성물 1

HCID 162792ZR 2646수율 89%

실험 절차

In pyridine (10ml) 1.2 g (5 mmol) of 1-(p-ethoxycarbonyl-phenoxy)-butan- 2-ol was dissolved and to this solution was gradually added 0.6 g (5 mmol) of pivaloyl chloride cooling in an ice bath. The mixture was stirred at room temperature for 3 hours after the addition was completed. During the course of the reaction pyridine hydrochloride precipitated. The reaction mixture was then poured in ice water and extracted with ethyl acetate. The extract was washed with water, dried, and concentrated to afford 1.6g of 1-(p-ethoxycarbonyl-phenoxy)-butan-2-ol pivalate (compound No. 1) in a yield of 89% as a light yellow viscous oily substance.

후처리

  1. additionafter the addition
  2. customprecipitated
  3. additionThe reaction mixture was then poured in ice water
  4. extractionextracted with ethyl acetate
  5. washThe extract was washed with water
  6. customdried
  7. concentrationconcentrated

출처 및 근거

ORD 기록
ord-0f22a9d3d5004617b51f20e6cd35464c
출처 데이터셋
uspto-grants-1977_04
특허 번호
US04016186

반응 노트

불러오는 중…