Nitric Acid → 2-(4-Methoxy-3-nitrophenyl)propanoic acid

HRID 328164

반응식

HRID 328164 반응식
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([CH:9]([CH3:13])[C:10]([OH:12])=[O:11])=[CH:5][CH:4]=1.[N+:14]([O-])([OH:16])=[O:15]>S(=O)(=O)(O)O>[N+:14]([C:8]1[CH:7]=[C:6]([CH:9]([CH3:13])[C:10]([OH:12])=[O:11])[CH:5]=[CH:4][C:3]=1[O:2][CH3:1])([O-:16])=[O:15]

참가 물질

4

반응물 2

HCID 944Nitric AcidHCID 257576p-Methoxyphenylpropionic acid

생성물 1

HCID 214441642-(4-Methoxy-3-nitrophenyl)propanoic acid

시약·촉매·용매 1

HCID 1118Sulfuric Acid용매

실험 절차

5.23g of 2-(4-methoxyphenyl)propionic acid was added gradually under cooling in a mixture of 27.5g of nitric acid and 19.9g of sulfuric acid. After the mixture was stirred at -10° C to -5° C for 6 hours, the mixture was poured into ice-water. The thus obtained oily substance was extracted with ethyl acetate. The extract was dried over magnesium sulfate and distilled off. The residue was purified by means of silica gel chromatography to give the object compound having m.p. 89° - 90° C in a yield of 5.0g (76%).

후처리

  1. extractionThe thus obtained oily substance was extracted with ethyl acetate
  2. dry with materialThe extract was dried over magnesium sulfate
  3. distillationdistilled off
  4. customThe residue was purified by means of silica gel chromatography
  5. customto give the object compound

출처 및 근거

ORD 기록
ord-b476517894b34ed79c4361eb6510c9fe
출처 데이터셋
uspto-grants-1977_04
특허 번호
US04016193

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