Allyl bromide → Ethyl 2-(3-nitro-4-allyloxyphenyl)propionate

HRID 328165노트

반응식

HRID 328165 반응식
[N+:1]([C:4]1[CH:5]=[C:6]([CH:11]([CH3:17])[C:12]([O:14][CH2:15][CH3:16])=[O:13])[CH:7]=[CH:8][C:9]=1[OH:10])([O-:3])=[O:2].[CH2:18](Br)[CH:19]=[CH2:20].C(=O)([O-])[O-].[K+].[K+]>CC(C)=O>[N+:1]([C:4]1[CH:5]=[C:6]([CH:11]([CH3:17])[C:12]([O:14][CH2:15][CH3:16])=[O:13])[CH:7]=[CH:8][C:9]=1[O:10][CH2:20][CH:19]=[CH2:18])([O-:3])=[O:2]

참가 물질

5

반응물 3

HCID 7841Allyl bromideHCID 11430Potassium CarbonateHCID 21444155Ethyl 2-(4-hydroxy-3-nitrophenyl)propanoate

생성물 1

HCID 21444159Ethyl 2-(3-nitro-4-allyloxyphenyl)propionate

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

A mixture of 2.39g of ethyl 2-(3-nitro-4-hydroxyphenyl)propionate, 1.45g of allylbromide and 1.65g of potassium carbonate in 20ml of acetone was refluxed for 4 hours. After cooling, the solvent was distilled under reduced pressure. The residue was dissolved in ethyl acetate and washed with water. After the solution was dried over magnesium sulfate, the solvent was distilled off. The thus obtained oily substance was purified by means of silica gel chromatography, to give the object compound in a yield of 2.51g (90%).

후처리

  1. temperaturewas refluxed for 4 hours
  2. temperatureAfter cooling
  3. distillationthe solvent was distilled under reduced pressure
  4. dissolutionThe residue was dissolved in ethyl acetate
  5. washwashed with water
  6. dry with materialAfter the solution was dried over magnesium sulfate
  7. distillationthe solvent was distilled off
  8. customThe thus obtained oily substance was purified by means of silica gel chromatography
  9. customto give the object compound in a yield of 2.51g (90%)

출처 및 근거

ORD 기록
ord-db37a75043164c6b8b4aa3f1463faeb9
출처 데이터셋
uspto-grants-1977_04
특허 번호
US04016193

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