Formaldehyde → 3-[N-(3-hydroxypropyl)methylamino]-N,N,N-trimethylpropan-1-aminium chloride hydrochloride

HRID 328184노트

반응식

HRID 328184 반응식
[Cl-:1].[CH:2]([N:4]([CH2:9][CH2:10][CH2:11][N+:12]([CH3:15])([CH3:14])[CH3:13])[CH2:5][CH2:6][CH2:7][OH:8])=O.C=O>C(O)=O>[ClH:1].[Cl-:1].[OH:8][CH2:7][CH2:6][CH2:5][N:4]([CH2:9][CH2:10][CH2:11][N+:12]([CH3:15])([CH3:14])[CH3:13])[CH3:2]

참가 물질

4

반응물 2

HCID 712FormaldehydeHCID 213163693-[N'-formyl-N'-(3-hydroxypropyl)amino]-N,N,N-trimethyl-1-propanaminium chloride

생성물 1

HCID 213163673-[N-(3-hydroxypropyl)methylamino]-N,N,N-trimethylpropan-1-aminium chloride hydrochloride

시약·촉매·용매 1

HCID 284Formic Acid용매

실험 절차

A mixture of 2 g. of 3-[N'-formyl-N'-(3-hydroxypropyl)amino]-N,N,N-trimethyl-1-propanaminium chloride 4 g. of 99% formic acid and 2 ml. of formalin is stirred and heated at 100° for 17 hours. To the cooled mixture is added 11 ml. of concentrated hydrochloric acid and the reaction mixture is concentrated under reduced pressure. The product is taken up in 35 ml. of 1 N hydrochloric acid and the solution is filtered and concentrated to dryness under reduced pressure yielding 3-[N'-(3-hydroxypropyl)-N'-methylamino]-N,N,N-trimethyl-1-propanaminium chloride hydrochloride.

후처리

  1. additionA mixture of 2 g
  2. temperatureheated at 100° for 17 hours
  3. additionTo the cooled mixture is added 11 ml
  4. concentrationof concentrated hydrochloric acid and the reaction mixture is concentrated under reduced pressure
  5. filtrationof 1 N hydrochloric acid and the solution is filtered
  6. concentrationconcentrated to dryness under reduced pressure

출처 및 근거

ORD 기록
ord-d9d42b07a44148eda82f8ac09fe1cb9a
출처 데이터셋
uspto-grants-1977_04
특허 번호
US04016209

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