1,1,2,2-Tetrachloroethylsulfenyl chloride → 6-propyl-1H-pyrimidin-4-one;hydrochloride

HRID 328199노트

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HRID 328199 반응식
S[C:2]1[N:7]=[C:6]([OH:8])[CH:5]=[C:4]([CH2:9][CH2:10][CH3:11])[N:3]=1.[Cl:12]C(Cl)(SCl)C(Cl)Cl>COCCOC>[ClH:12].[OH:8][C:6]1[CH:5]=[C:4]([CH2:9][CH2:10][CH3:11])[N:3]=[CH:2][N:7]=1

참가 물질

4

반응물 2

HCID 144531,1,2,2-Tetrachloroethylsulfenyl chlorideHCID 178439476HCID 178439476, 화합물

생성물 1

HCID 1784394686-propyl-1H-pyrimidin-4-one;hydrochloride

시약·촉매·용매 1

HCID 80711,2-Dimethoxyethane용매

실험 절차

To a slurry of 5.0 g (0.029 mol) of 2-mercapto-4-hydroxy-6-propyl pyrimidine in 50 ml of 1,2-dimethoxyethane was added 6.9 g (0.029 mol) of 1,1,2,2-tetrachloroethylsulfenyl chloride. The resulting mixture was heated at the reflux temperature for 10 minutes, and then filtered while still hot. The solvent was removed by evaporation under reduced pressure to give 8.8 g of 1,1,2,2-tetrachloroethylsulfenylmercapto)-4-hydroxy-6-propyl pyrimidine hydrochloride having a melting point of 142°-144° C. Analysis was as follows: %Cl, calc., 43.8, found 43.0; %S, calc. 15.8, found 15.5.

후처리

  1. temperatureThe resulting mixture was heated at the reflux temperature for 10 minutes
  2. filtrationfiltered while still hot
  3. customThe solvent was removed by evaporation under reduced pressure

출처 및 근거

ORD 기록
ord-96dae9673bb64a038e2e1928c5909d00
출처 데이터셋
uspto-grants-1977_04
특허 번호
US04016275

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